Cytokines mediate increased endothelial-leukocyte interaction and brain capillary plugging during CAR T cell neurotoxicity
Lina Park, Yu-Tung Tsai, Ruoqian Hu, Hyun‐Kyoung Lim, Lila D. Faulhaber, Katelyn Burleigh, Mahashweta Bose, Eli M. Faulhaber, Isabella H. Draper, Stephen E.P. Smith, Andy Y. Shih, Alexandre V. Vinaud Hirayama, Cameron John Turtle, Colleen Annesley, Rebecca Alice Gardner, , Juliane Gust
CAR T cell therapy causes cytokine release, leading to increased endothelial-leukocyte interactions and brain capillary plugging, which correlates with neurotoxicity.
bioRxiv · Feb 19, 2025 · PreprintImmunology