Andy Y. Shih

The paper examines the organization of axons around cortical vasculature in mice, finding that axons form micro-tracts around capillaries, which may facilitate neurovascular coupling.

This study identifies perivascular fibroblasts as regulators of cerebral vasomotion and cerebrospinal fluid movement through calcium dynamics and Gq signaling.

This study identifies spatial and dynamic molecular heterogeneity in adult mouse brain pericytes across anatomical regions, vascular positions, aging, ischemia, and circadian phases.

This study uses chemogenetic activation of pericytes in mice to show their ability to contract capillaries and cause hypoperfusion, particularly in limbic regions.

This study examines microglial dynamics across different life stages, showing significant morphological and functional changes in response to injury.

CAR T cell therapy causes cytokine release, leading to increased endothelial-leukocyte interactions and brain capillary plugging, which correlates with neurotoxicity.

The paper shows that capillary injury and regression lead to sustained vasoconstriction in upstream vessels, reducing blood flow in both injured and uninjured regions of the microvascular network.

The paper shows that impaired capillary-venous drainage in aging mice leads to hypoperfusion, gliosis, and demyelination in deep white matter regions.

This study tracks the origin and development of perivascular fibroblasts in postnatal mice, showing they originate from the meninges and expand via proliferation and migration to cover cerebral vasculature by P14.

The paper examines how endothelial cell structure influences capillary diameter heterogeneity in mouse brain microvasculature using electron microscopy data.

This paper develops an optogenetic method to control arteriole diameter in 3D with high spatiotemporal resolution, enabling study of vascular dynamics and blood flow regulation.

This study shows that pericyte loss in aged brains leads to capillary dilation, flow heterogeneity, and structural disruption, highlighting pericyte remodeling as a therapeutic target.

The paper presents a meta-analysis of electron microscopy datasets to explore cerebrovascular structures and identifies features important for vascular function and segmentation improvements.

The paper uses in vivo two-photon imaging to distinguish perivascular fibroblasts from mural cells in mouse cerebral cortex, revealing unique structural and distributional features.

This study identifies brain capillary obstruction and hypoxia as mechanisms of neurotoxicity in CD19-CAR T cell therapy using a mouse model.

This study shows capillary pericytes influence blood flow but with slower kinetics than upstream cells, and their removal increases blood flow.

This study uses in vivo two-photon imaging to show chronic ethanol exposure alters sensory-evoked neuronal and vascular responses in mice, with region-specific neurovascular coupling changes.

The paper identifies two transitional mural cell types in adult mouse cortex with distinct -smooth muscle actin levels and morphological features.

This study shows that aged SCD mice develop cerebral vasculopathy features seen in humans, with increased RBC velocity, occlusive events, and microinfarcts detected via in vivo two-photon imaging.