Prophylactic and therapeutic antiviral effects of the influenza A defective interfering particle OP7 in human lung epithelial cells in vitro
Patricia Opitz, Jan Küchler, Kristina Marie Holdt, Elias Hofmann, Daniel Rüdiger, Sascha Young Kupke, Udo Reichl
This study demonstrates that OP7, an unconventional influenza A defective interfering particle, effectively inhibits viral replication in human lung cells through both direct interference and IFN induction, supporting its potential as an antiviral agent.
bioRxiv · Mar 31, 2026 · PreprintMolecular Biology