Author

Daniel Rüdiger

Max Planck Institute for Dynamics of Complex Technical SystemsORCID 0000-0002-7817-1884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Sascha Young KupkeiD· 3 shared Udo ReichliD· 3 shared Jan KüchleriD· 2 shared Patricia OpitziD· 2 shared Elias Hofmann· 1 shared Julita PiaseckaiD· 1 shared Kristina Marie Holdt· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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3 shared papersMolecular Biology

Sascha Young KupkeORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 22, 2026

Model-Guided Engineering of NS1-Truncated Influenza OP7 Particles with Enhanced Interferon-Mediated Antiviral Activity

Julita Piasecka, Daniel Rüdiger, Udo Reichl, Sascha Young Kupke

This study engineers a modified DIP by truncating NS1 to enhance antiviral activity, showing improved inhibition of IAV replication and IFN response.

DOI 10.64898/2026.09.18.752587

humanstatistical model

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Systems BiologybioRxivPreprintSep 11, 2026

Data-driven multiscale modeling deciphers MOI-dependent dual antiviral mechanisms of OP7

Daniel Rüdiger, Patricia Opitz, Jan Küchler…·Sascha Young Kupke

This paper develops a multiscale model of IAV and OP7 coinfection, revealing MOI-dependent antiviral mechanisms and predicting therapeutic efficacy.

1 citation

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintMar 31, 2026

Prophylactic and therapeutic antiviral effects of the influenza A defective interfering particle OP7 in human lung epithelial cells in vitro

Patricia Opitz, Jan Küchler, Kristina Marie Holdt…·Udo Reichl

This study demonstrates that OP7, an unconventional influenza A defective interfering particle, effectively inhibits viral replication in human lung cells through both direct interference and IFN induction, supporting its potential as an antiviral agent.

1 citation

humanexperimental assay

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