Author

Jan Küchler

Max Planck Institute for Dynamics of Complex Technical SystemsORCID 0009-0003-6479-1825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Udo ReichliD· 4 shared Sascha Young KupkeiD· 3 shared Daniel RüdigeriD· 2 shared Dirk BenndorfiD· 2 shared Patricia OpitziD· 2 shared Yvonne GenzeliD· 2 shared Achim Dieter GruberiD· 1 shared Dunja BruderiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMolecular Biology

Udo ReichlORCID

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4 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 11, 2026

Data-driven multiscale modeling deciphers MOI-dependent dual antiviral mechanisms of OP7

Daniel Rüdiger, Patricia Opitz, Jan Küchler…·Sascha Young Kupke

This paper develops a multiscale model of IAV and OP7 coinfection, revealing MOI-dependent antiviral mechanisms and predicting therapeutic efficacy.

1 citation

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintMar 31, 2026

Prophylactic and therapeutic antiviral effects of the influenza A defective interfering particle OP7 in human lung epithelial cells in vitro

Patricia Opitz, Jan Küchler, Kristina Marie Holdt…·Udo Reichl

This study demonstrates that OP7, an unconventional influenza A defective interfering particle, effectively inhibits viral replication in human lung cells through both direct interference and IFN induction, supporting its potential as an antiviral agent.

1 citation

humanexperimental assay

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Molecular BiologybioRxivPreprintJun 25, 2025

Quantitative analysis of proteomic changes in monoclonal MDCK cell lines infected with human influenza A virus

Jan Küchler, Tilia Zinnecker, Patrick Hellwig…·Udo Reichl

The paper compares proteomic changes in two monoclonal MDCK cell lines infected with influenza A virus to identify factors associated with high viral yield.

DOI 10.1101/2025.06.25.661656

proteomicsstatistical model

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Molecular BiologyScientific ReportsPeer-reviewedNov 28, 2023

Generation of OP7 chimera defective interfering particle preparations free of infectious influenza A virus that shows antiviral efficacy in mice

Tanya Dogra, Lars Pelz, Julia Désirée Boehme…·Udo Reichl

10 citations

mouseexperimental assay

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