TNFα-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons
Alicia González Díaz, Elisa Belli, Benedetta Mannini, Gustavo Antonio Urrutia, Michele Vendruscolo
This study develops a human iPSC-derived cortical neuron model that recapitulates AD pathology through TNFα treatment, showing Aβ aggregation, synaptic dysfunction, and hypermetabolism.
bioRxiv · Aug 30, 2024 · PreprintCell Biology