Alicia González Díaz

Organization of the Proteostasis Network of Membraneless Organelles

The paper maps the proteostasis network of membraneless organelles, revealing the role of anabolic components and molecular chaperones in regulating protein conformations.

A human neuronal model of sporadic Alzheimer's disease induced by FBXO2 downregulation shows A β aggregation, tau hyperphosphorylation and functional network impairment

This study shows that downregulating FBXO2 in human iPSC-derived neurons leads to Alzheimer's disease-like features including Aβ aggregation and tau hyperphosphorylation.

In situ generation of Aβ42 oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neurons

This study generates Aβ42 oligomers in human iPSC-derived neurons to model Alzheimer's disease and assess inhibitor effects.

TNFα-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons

This study develops a human iPSC-derived cortical neuron model that recapitulates AD pathology through TNFα treatment, showing Aβ aggregation, synaptic dysfunction, and hypermetabolism.