Author

Benedetta Mannini

University of CambridgeORCID 0000-0001-6812-7348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Assay:electrophysiology· 1 Assay:imaging· 1

Frequent Co-Authors

Alicia González DíaziD· 3 shared Gustavo Antonio Urrutia· 3 shared Michele VendruscoloiD· 3 shared Andrea Possenti· 2 shared Yuqi Bian· 2 shared Christine Maria LimiD· 1 shared Danilo LicastroiD· 1 shared David KlenermaniD· 1 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCell Biology

Alicia González DíazORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 1, 2024

A human neuronal model of sporadic Alzheimer's disease induced by FBXO2 downregulation shows A β aggregation, tau hyperphosphorylation and functional network impairment

Alicia González Díaz, Andrea Possenti, Gustavo Antonio Urrutia…·Michele Vendruscolo

This study shows that downregulating FBXO2 in human iPSC-derived neurons leads to Alzheimer's disease-like features including Aβ aggregation and tau hyperphosphorylation.

DOI 10.1101/2024.09.01.610673

humanbulk RNA-seq

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Cell BiologybioRxivPreprintAug 30, 2024

In situ generation of Aβ42 oligomers via secondary nucleation triggers neurite degeneration and synaptic dysfunction in human iPSC-derived glutamatergic neurons

Alicia González Díaz, Eleonora Sarracco, Andrea Possenti…·Michele Vendruscolo

This study generates Aβ42 oligomers in human iPSC-derived neurons to model Alzheimer's disease and assess inhibitor effects.

2 citations

humanexperimental assay

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Cell BiologybioRxivPreprintAug 30, 2024

TNFα-driven Aβ aggregation, synaptic dysfunction and hypermetabolism in human iPSC-derived cortical neurons

Alicia González Díaz, Elisa Belli, Benedetta Mannini…·Michele Vendruscolo

This study develops a human iPSC-derived cortical neuron model that recapitulates AD pathology through TNFα treatment, showing Aβ aggregation, synaptic dysfunction, and hypermetabolism.

1 citation

humanproteomics

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