Fully Human Stem Cell-Derived BBB Model for Clinical Disease Modeling and Neurotropic AAV selection
Angelo Iannielli, Serena Gea Giannelli, Thomas Behrens, Mirko Luoni, Sharon Muggeo, Giosuè Moscato, Martina Greco, Elisa Enzi, Rita El Khoury, Elena Criscuolo, Monica Casucci, Nicola Clementi, Josep María Canals, Raffaele Iorio, Vania Broccoli
This paper develops a fully human stem cell-derived BBB model to study disease mechanisms and evaluate neurotropic AAV capsids.
bioRxiv · Dec 23, 2025 · PreprintNeuroscience