Mirko Luoni

This study introduces TES, an epigenetic silencer targeting YAP/TAZ-TEAD axis in GBM, which suppresses tumor growth and invasiveness while being safe for normal cells.

This paper develops a fully human stem cell-derived BBB model to study disease mechanisms and evaluate neurotropic AAV capsids.

This paper develops AAV-STITCH, a method to target neuroblastoma cells using anti-GD2 ScFv coupled to AAV capsids, showing selective transduction and tumor suppression in mouse models.

This study identifies MCT1-dependent metabolic failure and neuroinflammation as key factors in optic nerve degeneration in Wolfram syndrome mice, suggesting therapeutic targets for early intervention.

The paper investigates region-specific rescue of KCC2 by rhIGF-1 and oxytocin in a mouse model of Rett syndrome, showing complementary effects in different brain regions.

AAV-PHP.eB-mediated delivery of an instability-prone Mecp2 transgene improves behavioral and molecular defects in Mecp2 mutant mice without severe toxicity.