Identification and characterization of nanobodies acting as molecular chaperones for glucocerebrosidase through a novel allosteric mechanism
Thomas Dal Maso, Chiara Sinisgalli, Gianluca Zilio, Elisa Franzin, Isabella Tessari, Els Pardon, Jan Steyaert, Steven Ballet, Elisa Greggio, Wim Versées, Nicoletta Plotegher
This study identifies nanobodies that act as molecular chaperones for glucocerebrosidase, improving its activity and stability, with potential therapeutic applications for Gaucher and Parkinson's diseases.
Nature Communications · May 27, 2025Peer-reviewedBiochemistry