Endosomal maturation is controlled by the trimeric Bulli-Mon1-Ccz1 GEF7 complex and Rab5-GTPase activating protein GAPsec
Maren Janz, Maik Drechsler, Heiko Meyer, Vikeraman Sriram, Kim Michelle Simes, Elisa Frommhold, Nadia Füllbrunn, Lars Langemeyer, Christian Ungermann, Daniel Kümmel, Achim Paululat
This study identifies GAPsec as a novel Rab5 GAP required for endosomal maturation in fruit fly nephrocytes, showing its role in endosome-lysosome fusion.
Journal of Cell Science · Apr 7, 2026Peer-reviewedCell Biology