Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations
Elise Drapé, Lauranne Carrier, Gaël Cagnone, Halima Drissi Touzani Walali, Mathilde Bizou, Patrick Piet Van Vliet, Grégor Andelfinger, Bruno Larrivée, Alexandre Dubrac
This study identifies a novel angiogenic endothelial cluster driven by loss of ALK1 signaling in brain arteriovenous malformations (bAVMs) and shows that KIT inhibition prevents bAVM formation.
bioRxiv · Jun 5, 2025 · PreprintCell Biology