Patrick Piet Van Vliet

Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution

This study uses single-cell RNA-seq to analyze transcriptional changes in mouse hearts during perinatal development, identifying gene regulatory patterns and a cell type-independent imprinted gene signature.

Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations

This study identifies a novel angiogenic endothelial cluster driven by loss of ALK1 signaling in brain arteriovenous malformations (bAVMs) and shows that KIT inhibition prevents bAVM formation.

Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue

The paper develops a human intestinal organoid model with macrophages to study their role in development, finding that macrophages regulate metabolism and growth without affecting tissue architecture.

A human cell model of cardiac pathophysiological valvulogenesis

This paper develops a human pluripotent stem cell model to study valvulogenesis and disease, showing it can recapitulate valve development and disease traits like mitral valve prolapse.