Grégor Andelfinger

Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution

This study uses single-cell RNA-seq to analyze transcriptional changes in mouse hearts during perinatal development, identifying gene regulatory patterns and a cell type-independent imprinted gene signature.

Synthetic analogue of adrenocorticotropic hormone, ACTH(4-7)PGP delays neurological manifestations in diseases of mucopolysaccharidosis III spectrum by reducing neuroinflammation and rescuing neurotransmission, synaptogenesis, and axonal demyelination

The paper tests a synthetic peptide ACTH(4-7)PGP in MPS III mouse models, showing it improves synaptic function, reduces neuroinflammation, and extends lifespan.

Heart-On-a-Chip with Integrated Ultrasoft Mechanosensors for Continuous Measurement of Cell- and Tissue-scale Contractile Stresses

This paper introduces a heart-on-a-chip platform with ultrasoft mechanosensors to measure cell- and tissue-scale contractile stresses, showing that ECM composition affects contractility and drug responses.

Patient-Specific 3D Heart-On-a-Chip Model of Dilated Cardiomyopathy with Embedded Bead-Based Mapping of Tissue Contractility

This paper develops a patient-specific heart-on-a-chip model for dilated cardiomyopathy, showing functional abnormalities and drug response.

Loss of endothelial ALK1 signaling induces the emergence of a KIT+ angiogenic endothelial cluster driving brain arteriovenous malformations

This study identifies a novel angiogenic endothelial cluster driven by loss of ALK1 signaling in brain arteriovenous malformations (bAVMs) and shows that KIT inhibition prevents bAVM formation.

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

Enhancing adult neuroplasticity by epigenetic regulation of Parvalbumin-expressing GABAergic cells

This study shows that reducing Hdac2 in PV+ cells enhances fear memory extinction in adults by downregulating Acan, a perineuronal net component.

Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue

The paper develops a human intestinal organoid model with macrophages to study their role in development, finding that macrophages regulate metabolism and growth without affecting tissue architecture.

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease

The paper identifies 21 candidate haploinsufficient genes associated with congenital heart disease through integrative analysis of CNVs and DNMs in CHD cases and controls.