NeuroscienceBiomedicine & PharmacotherapyPeer-reviewed
Impairment of brain function in a mouse model of Alzheimer's disease during the pre-depositing phase: the role of alpha7 nicotinic acetylcholine receptors
Olena Lykhmus, Wen-Yu Tzeng, Lyudmyla Koval…·Maryna V. Skok
This study shows that in a mouse model of Alzheimer's disease, before amyloid deposition, there are increased inflammatory markers, reduced nicotinic acetylcholine receptors, and impaired memory, which can be mitigated by targeting alpha7 nAChRs.
8 citations