Wen-Yu Tzeng

The paper identifies a stable, glomerulus-specific basal activity map in the olfactory bulb that supports olfactory-driven behavior and is disrupted in early Alzheimer's disease.

This study shows that in a mouse model of Alzheimer's disease, before amyloid deposition, there are increased inflammatory markers, reduced nicotinic acetylcholine receptors, and impaired memory, which can be mitigated by targeting alpha7 nAChRs.