A single cell transcriptomic fingerprint of stressed premature, imbalanced differentiation of embryonic stem cells.
Ximena Lu Ruden, Aditi Singh, Teya Marben, Wen Tang, Awoniyi Olumide Awonuga, Douglas Mark Ruden, Elizabeth Ella Puscheck, Hao Feng, Steven J. Korzeniewski, Daniel Allen Rappolee
The paper uses scRNA-seq to show hyperosmotic stress induces premature lineage imbalance in ESCs by increasing XEN and endoderm subpopulations and reducing naive pluripotency.
Birth Defects Research · Oct 31, 2024Peer-reviewedDevelopmental Biology