Wen Tang

SMORE performs joint dimensionality reduction and cell population discovery on single-cell methylome data, accurately recovering population structures in human datasets.

The paper uses scRNA-seq to show hyperosmotic stress induces premature lineage imbalance in ESCs by increasing XEN and endoderm subpopulations and reducing naive pluripotency.

imply improves cell-type deconvolution by using personalized reference panels, showing reduced bias and better alignment with biological facts in real data.

magpie evaluates statistical power for differential RNA methylation analysis in m6A sequencing by simulating data and assessing factors like sample size and effect size.