Hao Feng

The paper introduces SPInfer, a workflow for spatial proteomic inference that improves cell segmentation in human brain tissue, enabling better biological discovery at population scale.

SMORE performs joint dimensionality reduction and cell population discovery on single-cell methylome data, accurately recovering population structures in human datasets.

This study shows that pair bonding in male mandarin voles increases DA release and alters activity in NAc shell D1 and D2 MSNs, with D2 MSN inhibition enhancing pair bond formation.

The paper uses scRNA-seq to show hyperosmotic stress induces premature lineage imbalance in ESCs by increasing XEN and endoderm subpopulations and reducing naive pluripotency.

imply improves cell-type deconvolution by using personalized reference panels, showing reduced bias and better alignment with biological facts in real data.

magpie evaluates statistical power for differential RNA methylation analysis in m6A sequencing by simulating data and assessing factors like sample size and effect size.

The paper investigates how allelic transcription factor binding influences transcriptional kinetics in human cell lines using scRNA-seq, finding strong correlations between eQTL effect sizes and burst frequency.

This study examines the relationship between sTREM2 and inflammatory activity in early stage Alzheimer's disease using clinical and biomarker-defined groups.

NeuCA improves scRNA-seq cell annotation by using a neural network to leverage hierarchical cell type structure, achieving better accuracy than existing methods.