Douglas Mark Ruden

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

The paper uses scRNA-seq to show hyperosmotic stress induces premature lineage imbalance in ESCs by increasing XEN and endoderm subpopulations and reducing naive pluripotency.