Developmental BiologyBirth Defects ResearchPeer-reviewed
A single cell transcriptomic fingerprint of stressed premature, imbalanced differentiation of embryonic stem cells.
Ximena Lu Ruden, Aditi Singh, Teya Marben…·Daniel Allen Rappolee
The paper uses scRNA-seq to show hyperosmotic stress induces premature lineage imbalance in ESCs by increasing XEN and endoderm subpopulations and reducing naive pluripotency.