Heterologous expression of the human cohesin complex in Saccharomyces cerevisiae results in a dominant-negative phenotype
Elizabeth Stephens, Akil Hamza, Maureen R M Driessen, Nigel J. O’Neil, Peter C. Stirling, Philip Hieter
This study shows that human cohesin cannot function in yeast and disrupts endogenous cohesin biology when expressed heterologously.
bioRxiv · Apr 7, 2026 · PreprintGenetics