Peter C. Stirling

The paper uses DepMap data to identify WDR89 as a genome maintenance factor through correlation analysis of genetic dependencies.

The paper investigates the mutational signature of CX5461, a photosensitiser, when combined with UVA light, showing increased SNV burden only in co-exposed cells.

This study shows that human cohesin cannot function in yeast and disrupts endogenous cohesin biology when expressed heterologously.

The paper identifies DNA2 nuclease activity as a preferred therapeutic target in cancer by showing its essential role in DNA repair and fitness, with specific sensitivity in ALT+ tumors.

This study shows that Cdc48 regulates the deposition of the splicing factor Hsh155 at intranuclear quality control sites and affects its stability and splicing function.

This study shows that EFTUD2 mutations cause mis-splicing of Mdm2, leading to increased P53 activity and craniofacial defects, which can be mitigated by P53 inhibitors.

This study shows that yeast splicing defects cause genome instability through gene expression changes and R-loop accumulation, which is worsened by loss of Mad1.

This study shows Sgs1 and BLM helicases prevent R-loop induced genome instability in yeast and human cells by reducing R-loop accumulation and mitigating replication-transcription collisions.

The paper quantifies gene-drug interactions in yeast using mutation rate and fitness, identifying synthetic hypermutation cases and revealing a translesion synthesis mechanism.