Author

Elizabeth Urbina

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Cícera Regina LazzarottoiD· 2 shared GaHyun LeeiD· 2 shared Shengdar Q. TsaiiD· 2 shared Varun KattaiD· 2 shared Yichao LiiD· 2 shared Ashley R. Flory· 1 shared Azusa MatsubaraiD· 1 shared Claire Greene Whitfield· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Cícera Regina LazzarottoORCID

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2 papers

Recent·Most cited

Frequent, context-dependent effects of human genetic variation on Cas9 activity revealed by population-scale GUIDE-seq-2 and deep combinatorial CHANCE-seq profiling

Ashley R. Flory, Cícera Regina Lazzarotto, Yichao Li, Jacqueline Chyr, Muyu Yang, Varun Katta, Elizabeth Urbina, GaHyun Lee, Rachael K. Wood, Azusa Matsubara, Claire Greene Whitfield, Sara R. Rashkin, Jian Ma, Yong Cheng, Shengdar Q. Tsai

The paper uses population-scale GUIDE-seq-2 and CHANCE-seq to analyze how genetic variants affect Cas9 activity, finding frequent context-dependent effects on off-target sites.

bioRxiv · Feb 10, 2025 · PreprintGenomics

CHANGE-seq-BE enables simultaneously sensitive and unbiased in vitro profiling of base editor genome-wide activity

Cícera Regina Lazzarotto, Varun Katta, Yichao Li, Elizabeth Urbina, GaHyun Lee, Shengdar Q. Tsai

The paper introduces CHANGE-seq-BE, a method for sensitive and unbiased profiling of base editor off-target effects in vitro.

bioRxiv · Mar 28, 2024 · PreprintGenomics