De novo design of RNA and nucleoprotein complexes
Andrew Favor, Riley N. Quijano, Elizaveta Chernova, Andrew Kubaney, Connor Weidle, Morgan A. Esler, Ryan McHugh, Ann Carr, Yang Hsia, David Juergens, Kenneth D. Carr, Paul T Kim, Yuliya Politanska, Enisha Sehgal, Paul S. Kwon, , David A. Baker
This paper introduces a generative diffusion model for de novo design of RNA and nucleoprotein complexes, validated experimentally with SHAPE-seq and electron microscopy.
bioRxiv · Oct 1, 2025 · PreprintBiochemistry