Ann Carr

The paper designs de novo proteins that form autocatalytic isopeptide bonds, enabling rigid covalent protein assemblies through intramolecular and intermolecular crosslinking.

This paper designs twistless alpha-helical repeat proteins that inhibit ice recrystallization with activity comparable to native ice-binding proteins.

This paper introduces a generative diffusion model for de novo design of RNA and nucleoprotein complexes, validated experimentally with SHAPE-seq and electron microscopy.