Yang Hsia

This paper designs protein assemblies that switch between structural states using engineered interfaces, demonstrating temperature-responsive transitions from capsids to 2D arrays.

This paper presents a modular strategy to design programmable, highly porous protein crystals with tunable architectures and composition, enabling applications in catalysis and biomedicine.

The paper designs de novo proteins that form autocatalytic isopeptide bonds, enabling rigid covalent protein assemblies through intramolecular and intermolecular crosslinking.

This study designs genetically encoded miniproteins to modulate FAK kinase activity, showing they can inhibit or activate FAK in vitro and in cells, and adapt them to target other kinases.

This study designs proteins to control the phase, form, and function of metal-carbonate materials, demonstrating their use as electrocatalysts for alkaline water splitting.

This paper introduces a generative diffusion model for de novo design of RNA and nucleoprotein complexes, validated experimentally with SHAPE-seq and electron microscopy.

The paper designs and characterizes a random protein walker that diffuses along a designed protein track, finding that walkers with more feet move faster.

The paper introduces a modular bond-centric design approach for protein assemblies, demonstrating the successful creation of multiple polyhedral cages, 2D arrays, and 3D lattices with high success rates.

This paper designs 3D protein crystals with specified lattice architectures using computational methods, achieving atomic accuracy and demonstrating successful experimental validation.

This paper computationally designs self-assembling protein rotary machines that sample internal rotational degrees of freedom based on energy landscapes.

This paper designs reconfigurable asymmetric protein assemblies using implicit negative design principles, enabling stable subunit exchange and diverse complex formations.

The paper introduces a computational method for designing rigid protein assemblies through three-body fusion and validates it experimentally with mass spectrometry and cryo-EM.