Connor Weidle

Discovering and designing multistate protein assemblies

This paper designs protein assemblies that switch between structural states using engineered interfaces, demonstrating temperature-responsive transitions from capsids to 2D arrays.

Distinct mechanisms of neutralization by antibodies targeting a conserved pneumovirus F epitope

This study identifies two antibody classes that neutralize pneumovirus by targeting a conserved epitope, revealing distinct mechanisms of action through structural and functional analyses.

Cryo-EM mapping of circumsporozoite protein epitope accessibility and visualization of antibody-induced shedding on Plasmodium falciparum sporozoites

This study uses cryo-EM to examine how antibodies against different PfCSP epitopes affect the structure and shedding of the circumsporozoite protein on Plasmodium falciparum sporozoites.

Templating and confining calcium phosphate mineralization within designed protein assemblies

This study shows that computationally designed proteins can template and confine hydroxyapatite mineralization, providing a framework for programmable protein-guided mineralization.

Controlling metal-carbonate phase, form, and function through de novo protein design

This study designs proteins to control the phase, form, and function of metal-carbonate materials, demonstrating their use as electrocatalysts for alkaline water splitting.

De novo design of protein nanoparticles with integrated functional motifs

This paper designs de novo protein nanoparticles with integrated functional motifs, demonstrating their ability to form structured assemblies and elicit immune responses in mice.

Atomically accurate de novo design of antibodies with RFdiffusion

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

Bottom-up design of calcium channels from defined selectivity filter geometry

This paper designs Ca2+ channels with specific selectivity filter geometries using a bottom-up approach, showing higher Ca2+ conductance and structural accuracy.

De novo design of RNA and nucleoprotein complexes

This paper introduces a generative diffusion model for de novo design of RNA and nucleoprotein complexes, validated experimentally with SHAPE-seq and electron microscopy.

De novo design of potent inhibitors of Clostridioides difficile toxin B

This paper designs potent small protein inhibitors of C. difficile toxin B using deep learning and Rosetta, showing high affinity and stability for potential clinical use.

Computational design of bifaceted protein nanomaterials

This paper presents a computational strategy to design bifaceted protein nanomaterials with two distinct sides, enabling anisotropic functionalization and controlled structural variation.

Solubilization of Membrane Proteins using designed protein WRAPS

This paper introduces WRAPs, designed proteins that solubilize membrane proteins without detergents, enabling structural studies and vaccine development.

A Multivalent Pan-Ebolavirus Nanoparticle Vaccine Provides Protection in Rodents from Lethal Infection by Adapted Zaire and Sudan Viruses

This study develops a multivalent nanoparticle vaccine against EBOV and SUDV, showing protection in rodents from lethal infection.

Protein identification using cryo-EM and artificial intelligence guides improved sample purification

This paper identifies an unknown contaminant in protein samples using Cryo-EM and AI tools, leading to improved purification protocols.

Accurate Computational Design of 3D Protein Crystals

This paper designs 3D protein crystals with specified lattice architectures using computational methods, achieving atomic accuracy and demonstrating successful experimental validation.