Loss of Acid Ceramidase in Myeloid Cells Protects from Chronic Colitis in IL10-Deficent Mice
Keila S. Espinoza, Brandon K Dahl, Jessica N. Wysong, Ella M. Ryan, Mary R. Gordon, Chelsea L. Doll, Marilyn T. Marron, Cameron A. Beard, Pujarini Dutta Dey, Richard J. Simpson, Justin M. Snider, Justin E. Wilson, Pawel R. Kiela, Ashley J. Snider
This study shows that loss of acid ceramidase in myeloid cells reduces inflammation and protects from chronic colitis in IL10-deficient mice by impairing immune cell recruitment and altering sphingolipid metabolism.
bioRxiv · Jan 6, 2026 · PreprintPhysiology