Justin E. Wilson

Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages

S. anginosus replicates intracellularly within macrophages and is sensed by the NLRP3 inflammasome to promote proinflammatory response.

Loss of Acid Ceramidase in Myeloid Cells Protects from Chronic Colitis in IL10-Deficent Mice

This study shows that loss of acid ceramidase in myeloid cells reduces inflammation and protects from chronic colitis in IL10-deficient mice by impairing immune cell recruitment and altering sphingolipid metabolism.

Impact of Absent in Melanoma 2 (AIM2) on Antigen-Specific CD4+ T cell Activation and Homeostasis.

This study investigates AIM2's role in CD4+ T cell activation and homeostasis, finding it promotes IL-2 production in vitro but not essential for in vivo functions like tumor control.

Impact of AIM2 on HNSCC Development

This study shows AIM2 restricts HNSCC progression by regulating IFNγ and adaptive immune responses in a mouse model.

Inhibition of PIM kinase in tumor associated macrophages suppresses inflammasome 1 activation and sensitizes prostate cancer to immunotherapy

This study shows that inhibiting PIM kinases in tumor-associated macrophages reduces inflammasome activation and improves response to immunotherapy in prostate cancer.