Aberrant NOTUM+ Program Induced in LGR5+ Crypt Base Columnar Cells Maintains an Immunosuppressive Niche in Colorectal Cancer
Julian Chua, Parnika Sakthivel, Arshdeep Kaur, Elleine Allapitan, Areeba Maqsood, Oliver F. Bathe, Parham Minoo, Arshad Ayyaz
The paper identifies a novel cancer cell subtype, canCBCs, in MSS CRC that maintains an immunosuppressive niche, and shows their ablation enhances CD8 T cell tumor clearance.
bioRxiv · Mar 10, 2025 · PreprintCancer Biology