Cancer BiologybioRxivPreprint
Aberrant NOTUM+ Program Induced in LGR5+ Crypt Base Columnar Cells Maintains an Immunosuppressive Niche in Colorectal Cancer
Julian Chua, Parnika Sakthivel, Arshdeep Kaur…·Arshad Ayyaz
The paper identifies a novel cancer cell subtype, canCBCs, in MSS CRC that maintains an immunosuppressive niche, and shows their ablation enhances CD8 T cell tumor clearance.
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