Author

Arshad Ayyaz

University of CalgaryORCID 0009-0004-8573-2012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:mouse· 3 Assay:scRNA-seq· 3 Assay:ATAC-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2

Frequent Co-Authors

Jeffrey L. WranaiD· 3 shared Arshdeep KauriD· 2 shared Julian ChuaiD· 2 shared Mardi FinkiD· 2 shared Masahiro NarimatsuiD· 2 shared Abilasha Rao‐BhatiaiD· 1 shared Adrian Kwan Ho LoeiD· 1 shared Alba Diz-MuñoziD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

Jeffrey L. WranaORCID

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Author profile →

4 papers

Recent·Most cited

Lgr5+ Stem Cells Maintain Apex Position in Cell Hierarchy of the Intestinal Epithelium During Homeostasis and Injury

Julian Chua, Lucy M. Driver, Masahiro Narimatsu, Mardi Fink, Lixia Luo, Joshua Tran, Arshdeep Kaur, Rida Habib, Jatin Roper, David G. Kirsch, Jeffrey L. Wrana, Chang‐Lung Lee, Arshad Ayyaz

This study shows Lgr5+ stem cells maintain intestinal epithelial homeostasis and drive regeneration after injury through WNT signaling.

bioRxiv · Nov 9, 2025 · PreprintCell Biology

Aberrant NOTUM+ Program Induced in LGR5+ Crypt Base Columnar Cells Maintains an Immunosuppressive Niche in Colorectal Cancer

Julian Chua, Parnika Sakthivel, Arshdeep Kaur, Elleine Allapitan, Areeba Maqsood, Oliver F. Bathe, Parham Minoo, Arshad Ayyaz

The paper identifies a novel cancer cell subtype, canCBCs, in MSS CRC that maintains an immunosuppressive niche, and shows their ablation enhances CD8 T cell tumor clearance.

bioRxiv · Mar 10, 2025 · PreprintCancer Biology

PIEZO-dependent mechano-sensing of the niche is essential for intestinal stem cell fate decision and maintenance

Meryem B. Baghdadi, Ronja M. Houtekamer, Louisiane Perrin, Abilasha Rao‐Bhatia, Myles Whelen, Linda Decker, Martin Bergert, Carlos Perez Gonzalez, Réda Bouras, Giacomo Gropplero, Adrian Kwan Ho Loe, Amin Afkhami-Poostchi, Xin Chen, Xi Huang, Stéphanie Descroix, , Tae-Hee Kim

This study shows PIEZO channels are essential for intestinal stem cell maintenance by sensing mechanical cues from their niche.

Science · Nov 28, 2024Peer-reviewedCell Biology

Chromatin Remodelling in Damaged Intestinal Crypts Orchestrates Redundant TGFβ and Hippo Signalling to Drive Regeneration

Mardi Fink, Kizito Njah, Shyam J. Patel, David P. Cook, Vanessa Man, Francesco Ruso, Arsheen M. Rajan, Masahiro Narimatsu, Andreea Obersterescu, Melanie Pye, Daniel Trcka, Kin Chan, Arshad Ayyaz, Jeffrey L. Wrana

The paper identifies revSCs as regenerative cells in damaged intestinal crypts, showing TGFβ and Hippo pathways are critical for their function and intestinal regeneration.

Nature Cell Biology · Nov 15, 2024Peer-reviewedMolecular Biology