Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding
Nikolaus Frischauf, Jürgen Strasser, Ellen G. F. Borg, Aran F. Labrijn, Frank J M Beurskens, Johannes Preiner
This study shows that IgG subclass complement activation depends on their ability to form oligomers on antigen surfaces, challenging the traditional view of C1 affinity.
Proceedings of the National Academy of Sciences · Oct 22, 2024Peer-reviewedImmunology