Jürgen Strasser

A kinetic model of antigen-dependent IgG oligomerization and complement binding

This paper develops a kinetic model to predict IgG oligomerization and complement binding, incorporating factors like IgG concentration, antigen density, and Fc mutants.

Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding

This study shows that IgG subclass complement activation depends on their ability to form oligomers on antigen surfaces, challenging the traditional view of C1 affinity.

Comprehensive label-free characterization of extracellular vesicles and their surface proteins

This study establishes quartz crystal microbalance (QCM) as a label-free method to characterize extracellular vesicles and their surface proteins, enabling improved quality control of EV-based therapeutics.