Hedgehog regulation of epithelial cell state and morphogenesis in the larynx
Janani Ramachandran, Weiqiang Zhou, Anna E Bardenhagen, Talia Nasr, Ellen R Yates, Aaron M. Zorn, Hongkai Ji, Steven A. Vokes
This study shows that Sonic hedgehog (SHH) signaling is critical for maintaining epithelial integrity in the larynx and anterior foregut, with SHH loss causing abnormal epithelial to mesenchymal transition and replacement by Pax-1 expressing cells.
eLife · Nov 18, 2022Peer-reviewedDevelopmental Biology