Talia Nasr

This study shows that Sonic hedgehog (SHH) signaling is critical for maintaining epithelial integrity in the larynx and anterior foregut, with SHH loss causing abnormal epithelial to mesenchymal transition and replacement by Pax-1 expressing cells.

This study identifies a HH-Foxf1-Rspo2 signaling axis critical for tracheal cartilage development and shows its disruption leads to tracheomalacia.

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.

This paper identifies HH/Gli-dependent cellular mechanisms, including endosome-mediated remodeling and matrix degradation, essential for tracheoesophageal separation in mouse and Xenopus embryos.