Aaron M. Zorn

The paper uses vessel organoids to study how different FOXF1 variants affect mesoderm and capillary development in humans, showing variant-specific disruptions and potential therapeutic rescue.

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

The paper updates the Alliance of Genome Resources' central infrastructure, adding tools and enhancing data management and curation capabilities.

This study uses human organoids to show RFX6 mutations cause duodenal malformations by disrupting PDX1 and other signaling pathways.

The paper shows that disruptions in endosomal trafficking of the Vangl-Celsr polarity complex cause congenital trachea-esophageal malformations in Xenopus, similar to human EA/TEF.

This study shows that Sonic hedgehog (SHH) signaling is critical for maintaining epithelial integrity in the larynx and anterior foregut, with SHH loss causing abnormal epithelial to mesenchymal transition and replacement by Pax-1 expressing cells.

This study identifies Ventx2's role in regulating respiratory progenitor cell number and differentiation timing in Xenopus, with potential implications for human respiratory development.

The paper identifies novel risk genes associated with EA/TEF through whole genome sequencing and functional validation using CRISPR-Cas9 in Xenopus.

The paper introduces the Xenopus Phenotype Ontology (XPO) to standardize phenotype data from Xenopus experiments and link them to human health and development.

The paper builds a genome-scale gene regulatory network for vertebrate mesendoderm development using multi-omic data integration and validates novel transcription factor interactions.

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

This study identifies a gene regulatory network involving Tbx5, RA, Hedgehog, and Wnt signaling that coordinates cardiopulmonary development.

ELeFHAnt harmonizes and annotates single-cell RNA-seq data using ensemble learning methods to integrate multiple references and compare annotations across datasets.

The paper shows SOX transcription factors mediate WNT/{beta}-catenin transcription independently of TCFs during hPSC differentiation into DE and NMPs.

This study identifies a HH-Foxf1-Rspo2 signaling axis critical for tracheal cartilage development and shows its disruption leads to tracheomalacia.

The paper identifies Sox17 and β-catenin interactions at enhancers that regulate endoderm gene expression and repression of mesectoderm fates during Xenopus gastrulation.

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.

This study identifies bidirectional Wnt signaling between endoderm and mesoderm as critical for tracheal identity in mouse and human, with implications for tissue repair.

This paper identifies HH/Gli-dependent cellular mechanisms, including endosome-mediated remodeling and matrix degradation, essential for tracheoesophageal separation in mouse and Xenopus embryos.