Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling
Christine Junhui Liu, Ellie M Ho, Alexander S. Enos, Urte Beatrice Baublyte, Isabel M Luna, Alexander R Kosche, Vikaas Singh Sohal
This study shows psilocybin improves cognitive flexibility in mice with specific circuit-level deficits, depending on the cause, and identifies cellular mechanisms underlying its therapeutic effects.
bioRxiv · Jul 9, 2026 · PreprintNeuroscience