Vikaas Singh Sohal

Smells like γ-synchrony: Insula-prefrontal communication depends on γ-synchrony and supports modality-specific changes in behavioral strategies

This study shows that gamma synchronization between insula and prefrontal cortex supports modality-specific shifts in behavioral strategies in mice.

Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling

This study shows psilocybin improves cognitive flexibility in mice with specific circuit-level deficits, depending on the cause, and identifies cellular mechanisms underlying its therapeutic effects.

Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior

The paper shows that gamma oscillations in the prefrontal cortex involve dynamic, cell-type-specific synchronization patterns that support flexible behavior.

Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility

The paper shows that plasticity at long-range GABAergic synapses from prefrontal PV neurons regulates cognitive flexibility through optogenetic and electrophysiological experiments.

Circuit inhibition promotes the dynamic reorganization of prefrontal task encoding to support cognitive flexibility

This study shows that circuit inhibition in the prefrontal cortex enables dynamic reorganization of task encoding, supporting cognitive flexibility by allowing rapid shifts in rule representations during learning.

Activity-induced weakening of hippocampal input to prefrontal VIP interneurons reshapes inhibitory microcircuit function: implications for spatial working memory task acquisition

The paper investigates how hippocampal input to prefrontal VIP interneurons changes with activity and affects spatial working memory task learning in mice.

Context-invariant socioemotional encoding by prefrontal ensembles

This study investigates how prefrontal neurons encode socioemotional information across different environments, finding that context and socioemotional representations overlap but remain orthogonal.

Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice.

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

A multi-institutional investigation of psilocybin's effects on mouse behavior

This study investigates psilocybin's effects on mouse behavior through a multi-laboratory collaboration, finding robust acute effects but inconsistent persistent effects.

Loss of the autism associated gene Tbr1 disrupts prediction and encoding by prefrontal ensembles during socioemotional behaviors

This study shows that loss of the autism gene Tbr1 impairs prefrontal ensemble stability and coordination during socioemotional behaviors in mice.

Circuit dissection and functional validation of a cross-species emotional biomarker

The paper identifies a cross-species emotional biomarker based on beta-frequency communication between the ventral hippocampus and basolateral amygdala, showing it causally modulates anxiety-related behaviors in mice and correlates with human mood and anxiety.

Selective Inhibitory Circuit Dysfunction after Chronic Frontal Lobe Contusion

This study identifies selective dysfunction in inhibitory circuits in the orbitofrontal cortex after TBI, linking it to cognitive inflexibility.

Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition

This study identifies prefrontal cortex long-range GABAergic projections to the hippocampus that enhance signal-to-noise ratio for object representations and promote object exploration.

Long-range inhibition synchronizes and updates prefrontal task activity

The paper identifies long-range inhibitory projections from prefrontal parvalbumin neurons that synchronize neural activity and enable behavioral strategy updates during cognitive tasks.

Rhythmic auditory stimulation rescues cognitive flexibility in mutant mice with impaired gamma synchrony

This study shows that 40 Hz auditory stimulation improves cognitive flexibility in Dlx5/6+/- mice with gamma synchrony deficits, but does not normalize gamma synchrony or provide lasting effects.

Convergence of clinically relevant manipulations on dopamine-regulated prefrontal activity underlying stress-coping responses

The paper identifies that dopamine D2 receptors enhance correlated prefrontal microcircuit activity, which is modulated by antidepressants and linked to stress-coping behaviors.

Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior

The paper shows that correlated neural activity in the prefrontal cortex encodes social behavior information, and this synergy is disrupted in Shank3-deficient mice.

Interhemispheric gamma synchrony between parvalbumin interneurons supports behavioral adaptation

This study shows that gamma synchrony between parvalbumin interneurons supports behavioral adaptation by enabling mice to update cue-reward associations.

The Tuberous Sclerosis gene, Tsc1, represses parvalbumin+/fast-spiking properties in somatostatin-lineage cortical interneurons

This study shows that loss of Tsc1 leads to PV expression and fast-spiking properties in SST+ cortical interneurons, reversible by rapamycin.