Discovery of first-in-class inhibitors of the TRF1-TIN2 protein-protein interaction by fragment screening
Giacomo Casale, Manjuan Liu, Yann‐Vaï Le Bihan, Oviya Inian, Ellie Stammers, John Caldwell, Rob L. M. van Montfort, Ian Collins, Sebastian Guettler
The paper identifies a first-in-class inhibitor of the TRF1-TIN2 protein-protein interaction using fragment screening and structural methods.
Scientific Reports · Nov 20, 2025Peer-reviewedBiochemistry