Author

Sebastian Guettler

Institute of Cancer ResearchORCID 0000-0002-3135-1546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Oviya InianiD· 2 shared Angela Dello StrittoiD· 1 shared Ceylan SönmeziD· 1 shared Charlotte E. L. Fisher· 1 shared Ellie Stammers· 1 shared Ethan N. LeeiD· 1 shared Ethan R. GarviniD· 1 shared Francisca LottersbergeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

Oviya InianORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistryNature GeneticsPeer-reviewedJul 1, 2026

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex

Murugesh Padmanarayana, Saira Sakalas, Parijat Sarkar…·Rajat Rohatgi

The paper systematically maps the sequence-function landscape of the WNT destruction complex using mutational scanning, identifying novel mutations and revealing substrate-assisted autoregulation mechanisms.

2 citations

humanexperimental assay

𝕏 PostBluesky

BiochemistryScientific ReportsPeer-reviewedNov 20, 2025

Discovery of first-in-class inhibitors of the TRF1-TIN2 protein-protein interaction by fragment screening

Giacomo Casale, Manjuan Liu, Yann‐Vaï Le Bihan…·Sebastian Guettler

The paper identifies a first-in-class inhibitor of the TRF1-TIN2 protein-protein interaction using fragment screening and structural methods.

DOI 10.1038/s41598-025-23858-3

protein structureexperimental assay

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BiochemistryNaturePeer-reviewedApr 16, 2025

Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Patrik Eickhoff, Ceylan Sönmez, Charlotte E. L. Fisher…·Max E. Douglas

The paper shows RAP1 inhibits DNA-PK's end joining function at telomeres by forming a complex with TRF2, preventing telomere fusions.

9 citationstop 4%

humanmouse

𝕏 PostBluesky