Author

John Caldwell

Institute of Cancer ResearchORCID 0000-0001-9141-5452Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

John Caldwell1 paper · University of Colorado Anschutz

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Rob L. M. van MontfortiD· 2 shared Yann‐Vaï Le BihaniD· 2 shared Agnieszka KonopackaiD· 1 shared Andrea ScarpinoiD· 1 shared Bachuki ShashikadzeiD· 1 shared Bjoern Schwalb· 1 shared Denise Winkler· 1 shared Ellie Stammers· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Rob L. M. van MontfortORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 2, 2026

Developing Potent and Selective TBK1 Molecular Glue Degraders for Cancer Immunotherapy

John Caldwell, Patrick R. A. Zanon, Iona Ferguson…·Zoran Ranković

This paper develops a first-in-class TBK1 molecular glue degrader, CCT412020, which enhances anti-tumour immunity and overcomes immune checkpoint blockade resistance.

2 citations

humanexperimental assay

𝕏 PostBluesky

BiochemistryScientific ReportsPeer-reviewedNov 20, 2025

Discovery of first-in-class inhibitors of the TRF1-TIN2 protein-protein interaction by fragment screening

Giacomo Casale, Manjuan Liu, Yann‐Vaï Le Bihan…·Sebastian Guettler

The paper identifies a first-in-class inhibitor of the TRF1-TIN2 protein-protein interaction using fragment screening and structural methods.

DOI 10.1038/s41598-025-23858-3

protein structureexperimental assay

𝕏 PostBluesky