Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis
Rocco Adiutori, Fabìola Puentes, Michael Bremang, Vittoria Lombardi, Irene Zubiri, Emanuela Leoni, Johan Aarum, Denise Sheer, Simon McArthur, Ian Pike, Andrea Malaspina
This study identifies circulating protein aggregates as a source of ALS biomarkers and therapeutic targets by showing their enrichment with brain proteins and pathological features.
bioRxiv · Apr 30, 2020 · PreprintNeuroscience