Author

Rocco Adiutori

Queen Mary University of LondonORCID 0000-0002-8219-5002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrea MalaspinaiD· 2 shared Denise SheeriD· 2 shared Johan AarumiD· 2 shared Claudia CabreraiD· 1 shared Emanuela Leoni· 1 shared Fabìola PuentesiD· 1 shared Gavin GiovannoniiD· 1 shared Ian PikeiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Andrea MalaspinaORCID

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2 papers

Recent·Most cited

Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates

Johan Aarum, Claudia Cabrera, Tania A Jones, Shiron Rajendran, Rocco Adiutori, Gavin Giovannoni, Michael R. Barnes, Andrea Malaspina, Denise Sheer

The paper shows that RNA prevents protein aggregation in cell lysates, and that RNA degradation leads to protein aggregation, with specific RNA structures being effective in maintaining protein solubility.

EMBO Reports · Sep 18, 2020Peer-reviewedMolecular Biology

Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis

Rocco Adiutori, Fabìola Puentes, Michael Bremang, Vittoria Lombardi, Irene Zubiri, Emanuela Leoni, Johan Aarum, Denise Sheer, Simon McArthur, Ian Pike, Andrea Malaspina

This study identifies circulating protein aggregates as a source of ALS biomarkers and therapeutic targets by showing their enrichment with brain proteins and pathological features.

bioRxiv · Apr 30, 2020 · PreprintNeuroscience