Denise Sheer

This study identifies FGFR alterations in pediatric gliomas, their association with specific histologies, and their response to targeted therapies.

The paper shows that RNA prevents protein aggregation in cell lysates, and that RNA degradation leads to protein aggregation, with specific RNA structures being effective in maintaining protein solubility.

This study identifies circulating protein aggregates as a source of ALS biomarkers and therapeutic targets by showing their enrichment with brain proteins and pathological features.