Author

Ian Pike

Proteome Sciences (United Kingdom)ORCID 0000-0002-3071-0041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1

Frequent Co-Authors

Amandine Flaig· 1 shared Anaïs-Camille Vreulx· 1 shared Andrea MalaspinaiD· 1 shared Audrey CouloniD· 1 shared Benjamin Grenier‐BoleyiD· 1 shared Charlotte Bauer· 1 shared Charlotte Delay· 1 shared Denise SheeriD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Amandine Flaig

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2 papers

Recent·Most cited

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaïs-Camille Vreulx, Amandine Flaig, Tiago Mendes, Sandrine Hughes, Benjamin Grenier‐Boley, Xavier Hanoulle, Florie Demiautte, Charlotte Bauer, Mikael Marttinen, Mari Takalo, Philippe Amouyel, Shruti Desai, , Julien Chapuis

The paper identifies FERMT2 as a key modulator of axon guidance and synaptic plasticity in an APP-dependent manner, linking its genetic risk variant to Alzheimer's disease through miRNA regulation.

Molecular Psychiatry · Nov 3, 2020Peer-reviewedNeuroscience

Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosis

Rocco Adiutori, Fabìola Puentes, Michael Bremang, Vittoria Lombardi, Irene Zubiri, Emanuela Leoni, Johan Aarum, Denise Sheer, Simon McArthur, Ian Pike, Andrea Malaspina

This study identifies circulating protein aggregates as a source of ALS biomarkers and therapeutic targets by showing their enrichment with brain proteins and pathological features.

bioRxiv · Apr 30, 2020 · PreprintNeuroscience