Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease
Ikechukwu B. Jacob, Akinkunmi O. Lawal, Salma S. Mahmoud, Emerson M. Kopsack, Erin S. Reynolds, Qinghe Meng, Hongkuan Fan, Paul T. Massa, Saravanan Thangamani, Hongpeng Jia, Guirong Wang
This study shows that different human SP-A variants affect SARS-CoV-2-induced lung disease severity by altering viral infectivity and immune gene expression.
Frontiers in Immunology · Apr 2, 2025Peer-reviewedImmunology