Author

Ikechukwu B. Jacob

SUNY Upstate Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Erin S. ReynoldsiD· 2 shared Hongpeng JiaiD· 2 shared Saravanan ThangamaniiD· 2 shared Akinkunmi O. LawaliD· 1 shared Amanda GemmitiiD· 1 shared Brian D. NicholasiD· 1 shared Emerson M. Kopsack· 1 shared Guirong WangiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Erin S. ReynoldsORCID

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Author profile →

2 papers

Recent·Most cited

Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease

Ikechukwu B. Jacob, Akinkunmi O. Lawal, Salma S. Mahmoud, Emerson M. Kopsack, Erin S. Reynolds, Qinghe Meng, Hongkuan Fan, Paul T. Massa, Saravanan Thangamani, Hongpeng Jia, Guirong Wang

This study shows that different human SP-A variants affect SARS-CoV-2-induced lung disease severity by altering viral infectivity and immune gene expression.

Frontiers in Immunology · Apr 2, 2025Peer-reviewedImmunology

Human Surfactant Protein A Alleviates SARS-CoV-2 Infectivity in Human Lung Epithelial Cells

Ikechukwu B. Jacob, Amanda Gemmiti, Weichuan Xiong, Erin S. Reynolds, Brian D. Nicholas, Saravanan Thangamani, Hongpeng Jia, Guirong Wang

This study shows human SP-A binds SARS-CoV-2 S protein and hACE2, inhibiting viral infectivity and reducing viral load in lung cells, and suggests SP-A levels in saliva correlate with COVID-19 severity.

bioRxiv · Apr 3, 2023 · PreprintMolecular Biology